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 Ancillary Studies

The National Children’s Study offers the opportunity for ancillary or supplemental studies to leverage on the NCS. During the Vanguard phase, these studies are called Supplemental Methodological Studies. During the Main Study, they will be referred to as adjunct studies. Ancillary studies are initiated, planned, implemented and funded from outside of the NCS.

For more information on Adjunct Studies

For more information on Supplemental Methodological Studies

Below please find a current list of our ongoing Supplemental Methodological Studies:

Supplemental Methodological Study Topic Principal Investigator Institution Description
Perinatal Genome Daniele Fallin Johns Hopkins University This study seeks to validate the use of  genetic, epigentic, and environmental exposure measures for gene-environment studies via evaluation of biospecimen, environmental and phenotypic data from 200 parent child dyads from the NCS Vanguard Study.
Pediatric Reference Intervals for Biomarkers of Normal Development Patricia Jones University of Texas Southwest This study seeks to establish pediatric reference intervals for a number of biomarkers using minimum sample volumes. Various methods are used to  delineate the normal developmental changes in a) steroid hormones and b) amino acids, which could be used to monitor nutritional adequacy  and developmental metabolic changes.
Longitudinal Analysis of Non-persistent Pesticides in Breast Milk Joseph Ferrario Environmental Protection Agency This study aims to evaluate potential infant exposure to pesticides through ingestion of breast milk.
Effectiveness of Pre-Pregnancy and Early Pregnancy Recruitment Zdenko Herceg International Agency for Research on Cancer (IARC) This study aims to study dried blood spots  from the time of birth for epigenetic changes,  and link these results with data such as birth weight, gestational age and gender, to analyze the relationship between birth factors and epigenetic changes. After proving the methodology to be appropriate, a later study could address the epigenetic signature at birth as a predictor of childhood leukemia.
DNA methylation in association with prenatal blood mercury levels Lynn Goldman George Washington University and Johns Hopkins University This study aims to determine if DNA methylation is associated with methylmercury in NCS newborns.
Environmental toxicants: analysis of Vanguard biospecimens (in conjunction with NCEH exposure report) Mary Mortensen National Center for Environmental Health/Centers for Disease Control and Prevention This study aims to analyze  environmental  toxins in biospecimens and will serve as a basis for the study of several relationships.
Efficacy of Fetal Ultrasound as a Predictor of Fetal Health Jessica Nelson Minnesota Department of Health This study examines the utility of using dried blood spots from newborns for measurement of mercury, and compares these blood spot measurements to those on maternal blood and on cord blood.  The study will shed light on the efficacy of using dried blood spots, and of NCS collection and handling procedures. The study will also provide insight into the absolute and relative costs of these methodologies.
Feasibility of measuring parent-infant social behavior as a potential predictor of social-emotional development and autism in NCS children (Under Review) Lane Strathearn Baylor College of Medicine The goal of this study is to test the feasibility and reliability of using a videotaped parent-infant behavior assessment in conjunction with the 12 month NCS visit, and to examine its predictive validity in identifying infants with developmental or behavioral problems at 18, 24 and 30 months. An important aspect of this study is to put into practice the relationship between the Program Office, Principal Investigator and Regional Operations Center in ancillary studies which involve participant interface.