If the applicant does not know which Centers or locations are appropriate for the specific Supplemental Methodological Study (SMS), the SMS Team will assist with establishing an appropriate connection. Identifying and obtaining concurrence of a specific Study Center(s) is not absolutely required prior to application submission. It is, however, to the applicant’s advantage to contact specific Study Centers early in the process of developing the proposal as the Study Center’s agreeing to implement an SMS is voluntary. The Study Center(s)/location(s) must be selected prior to final approval of an SMS.