Public-private partnerships are mechanisms that allow for involvement of private, commercial, and not-for-profit organizations to support the National Children’s Study in a variety of ways. These include direct funding of portions of the Study as well as in-kind contributions of goods or services. During the Vanguard phase, proposal and funding of Supplemental Methodologic Studies is an opportunity for partners to directly support a focused methodological inquiry. For the Main Study, proposal and funding of Adjunct Studies is a similar option. Regarding goods and services, examples might be provision of gifts of appreciation or funding seasonal gatherings for Study participants. Opportunities for public-private partnerships will evolve in accordance with the progressive status of the Study.